Eminyakeni engaphezu kuka-2 000 edlule, uHippocrates, uyise wezokwelapha zanamuhla, wasikisela ukuthi zonke izifo ziqale emathunjini.
Nakuba okunye ukuhlakanipha kwakhe kuye kwahlala isikhathi eside, ungase uzibuze ukuthi wayeqinisile yini kule ndaba.
Lesi sihloko sikutshela konke okudingeka ukwazi mayelana nokuxhumana phakathi kwamathumbu akho kanye nobungozi besifo.
Uhlu lokuqukethwe
Ingozi Yezifo kanye Amathumbu Akho
Nakuba uHippocrates wayenephutha ngokusikisela lokho bonke Isifo siqala emathunjini akho, ubufakazi bukhombisa ukuthi izifo eziningi ezingapheli ze-metabolic ziyakwenza.
Amagciwane akho amathumbu kanye nobuqotho bolwelwesi lwamathumbu akho kuyithinta kakhulu impilo yakho. ().
Ngokocwaningo oluningi, imikhiqizo yebhaktheriya engafuneki ebizwa ngokuthi ama-endotoxins kwesinye isikhathi ingangena olwelweni lwakho lwamathumbu bese ingena egazini lakho ().
Amasosha akho omzimba abe esebona la ma-molecule angaphandle futhi awahlasele, okuholela ekuvuvukeni okungapheli ().
Abanye bacabanga ukuthi lokhu kuvuvukala okubangelwa ukudla kungase kubangele i-insulin nezici ezihlobene ne-insulin ohlotsheni lwesifo sikashukela sohlobo 2 kanye nokukhuluphala, ngokulandelana. Kukholelwa futhi ukuthi kubangela isifo sesibindi esinamafutha.
Okungenani, ukuvuvukala kuye kwaxhunyaniswa kakhulu nezifo eziningi ezimbi kakhulu emhlabeni (, , ).
Noma kunjalo, khumbula ukuthi le ndawo yocwaningo ikhula ngokushesha futhi imibono yamanje ingase ibuyekezwe ngokuzayo.
ABSTRACT
Nakuba kungezona zonke izifo eziqala emathunjini, izimo eziningi ze-metabolic ezingapheli kucatshangwa ukuthi zibangelwa noma zithonywa ukuvuvukala okungapheli kwamathumbu.
Imiphumela yokuvuvukala okungapheli
Ukuvuvukala yindlela amasosha akho omzimba asabela ngayo kubahlaseli bakwamanye amazwe, ubuthi, noma ukulimala kwamaseli.
Inhloso yawo ukusiza umzimba wakho ukuba uhlasele laba bahlaseli abangafuneki futhi uqale ukulungisa izakhiwo ezilimele.
Ukuvuvukala okunamandla (isikhashana), okufana nangemuva kokulunywa yizinambuzane noma ukulimala, ngokuvamile kuthathwa njengento enhle. Ngaphandle kwawo, amagciwane afana namagciwane namagciwane angangena kalula emzimbeni wakho, abangele ukugula noma ngisho nokufa.
Nokho, olunye uhlobo lokuvuvukala - olubizwa ngokuthi ukuvuvukala okungapheli, okuphansi, noma okuhlelekile - kungaba yingozi ngoba kuthatha isikhathi eside, kungathinta umzimba wakho wonke, futhi kuhlasele amangqamuzana omzimba wakho ngokungafanele (, ).
Isibonelo, imithambo yakho yegazi, njengemithambo yenhliziyo, ingase ivuvuke, njengoba kungase kube nezakhiwo ebuchosheni bakho (, ).
Ukuvuvukala okungapheli kwesistimu manje sekucatshangwa ukuthi kuyimbangela eyinhloko yezinye zezifo ezimbi kakhulu emhlabeni ().
Lokhu kufaka phakathi ukukhuluphala, isifo senhliziyo, uhlobo lwe-2 yesifo sikashukela, i-metabolic syndrome, isifo se-Alzheimer, ukucindezeleka nabanye abaningi (, , , , ).
Nokho, izimbangela eziqondile zokuvuvukala okungapheli okwamanje azikaziwa.
ABSTRACT
Ukuvuvukala yindlela amasosha akho omzimba asabela ngayo kubahlaseli bakwamanye amazwe, ubuthi, nokulimala kwamaseli. Ukuvuvukala okungapheli - okubandakanya umzimba wakho wonke - kucatshangwa ukuthi kuyimbangela yezifo eziningi ezimbi.
I-Endotoxins kanye ne-Leaky Gut
Ithumbu lakho liyikhaya lezigidigidi zamabhaktheriya - ngokuhlanganyela aziwa ngokuthi yi-gut flora ().
Nakuba amanye ala magciwane ezuzisa, amanye awazuzi. Ngenxa yalokho, inani nokwakheka kwamabhaktheriya akho amathumbu kungathinta kakhulu impilo yakho engokomzimba nengqondo ().
Izindonga zamaseli zamanye amagciwane akho amathumbu - abizwa nge-Gram-negative bacteria - aqukethe ama-lipopolysaccharides (LPS), ama-molecule amakhulu aziwa nangokuthi ama-endotoxins (, ).
Lezi zinto zingabangela ukusabela komzimba ezilwaneni. Ngesikhathi sokutheleleka kwebhaktheriya okunamandla, angabangela umkhuhlane, ukucindezeleka, ubuhlungu bemisipha kanye nokushaqeka kwe-septic ().
Ukwengeza, lezi zinto ngezinye izikhathi zingaphuma emathunjini ziye egazini, njalo noma ngemva nje kokudla (, ).
Ama-endotoxins angadluliselwa egazini lakho namafutha okudla noma adlule ezimpambanweni eziqinile okufanele zivimbele izinto ezingafuneki ukuthi zidlule olwelweni lwakho lwamathumbu (, ).
Uma lokhu kwenzeka, bavula amaseli omzimba. Nakuba amanani awo emancane kakhulu ukuthi angabangela izimpawu zokutheleleka njengemfiva, aphakeme ngokwanele ukuvusa ukuvuvukala okungapheli, okubangela izinkinga ngokuhamba kwesikhathi (, ).
Ngakho-ke, ukwanda kwamathumbu emathunjini - noma amathumbu avuzayo - kungase kube indlela eyinhloko yokuvuvukala okungapheli okubangelwa ukudla.
Lapho amazinga e-endotoxin egazini lakho enyuka aze afike ezingeni eliphindwe izikhathi ezi-2 kuye kwezingu-3 kunokuvamile, lesi simo saziwa ngokuthi i-metabolic endotoxemia ().
ABSTRACT
Amanye amabhaktheriya emathunjini akho aqukethe izingxenye zodonga lweseli ezibizwa nge-lipopolysaccharides (LPS) noma ama-endotoxin. Lokhu kungavuza emzimbeni wakho futhi kubangele ukuvuvukala.
Ukudla okungenampilo kanye ne-endotoxemia
Ucwaningo oluningi lwe-endotoxemia lujova ama-endotoxins egazini lezilwane ezihlolwayo nakubantu, okuye kwaboniswa ukuthi kubangele ukuqala ngokushesha kokumelana ne-insulin - isici esiyinhloko se-metabolic syndrome kanye nesifo sikashukela sohlobo 2 ().
Kuphinde kuholele ekwandeni okusheshayo kwezimpawu zokuvuvukala, okubonisa ukuthi impendulo yokuvuvukala yenziwe yasebenza ().
Ukwengeza, ucwaningo lwezilwane nolwabantu lubonisa ukuthi ukudla okungenampilo kungaholela emazingeni aphezulu e-endotoxins.
Ucwaningo lwezilwane lubonisa ukuthi ukudla okunamafutha amaningi isikhathi eside kungabangela i-endotoxemia, kanye nokuvuvukala, ukumelana ne-insulin, ukukhuluphala, kanye nezifo ze-metabolic ngenxa yalokho (, , ).
Ngokufanayo, ocwaningweni lomuntu lwenyanga eyodwa kubantu abangu-8 abanempilo, ukudla okuvamile kwaseNtshonalanga kubangele ukwanda kwe-71% emazingeni e-endotoxin yegazi, kuyilapho amazinga ehla ngo-31% kubantu abalandela ukudla okunamafutha aphansi ().
Ezinye izifundo eziningi zabantu ziye zaqaphela ukuthi amazinga e-endotoxin ayanda ngemva kokudla okungenamsoco, okuhlanganisa ukhilimu ohlanzekile, kanye nokudla okunamafutha amaningi kanye nokudla okunamafutha aphakathi (,,,,,).
Kodwa-ke, ngenxa yokuthi ukudla okuningi okunamafutha aphezulu noma ukudla kwakuqukethe ama-carbohydrate acwengiwe kanye nezithako ezicutshungulwayo, le miphumela akufanele ifanekiselwe ekudleni okunempilo, okunamafutha amaningi okusekelwe ekudleni kwangempela futhi kuhlanganise nenqwaba ye-fiber.
Abanye abacwaningi bakholelwa ukuthi ama-carbohydrate acwengiwe akhuphula amagciwane akhiqiza i-endotoxin kanye nokungena emathunjini, okukhulisa ukuchayeka kwe-endotoxin ().
Ucwaningo lwesikhathi eside ezinkawini ezidla ukudla okunezinga eliphezulu lusekela le nkolelo-mbono ().
I-Gluten ingase futhi ikhulise ukungena kwamathumbu ngenxa yemiphumela yayo ku-molecule ye-zonulin (, ).
Izimbangela eziqondile zokudla ze-endotoxemia azikaziwa okwamanje. Eqinisweni, izici ezimbalwa ezingase zidlale - ezibandakanya izingxenye zokudla, ukumiswa kwebhaktheriya yakho yamathumbu, nezinye izici eziningi.
ABSTRACT
Ucwaningo lwezilwane nolwabantu lukhombisa ukuthi ukudla okungenampilo kungakhuphula amazinga e-endotoxin egazini lakho, okungaholela esifweni se-metabolic.
Iphuzu elibalulekile
Izifo eziningi ze-metabolic ezingapheli kucatshangwa ukuthi ziqala emathunjini, futhi ukuvuvukala okuhlala isikhathi eside kubhekwa njengento ehamba phambili.
Ukuvuvukala okubangelwa ama-endotoxins ebhaktheriya kungase kube isixhumanisi esingekho phakathi kokudla okungenampilo, ukukhuluphala kanye nezifo ezingapheli ze-metabolic.
Nokho ukuvuvukala okungapheli kuyinkimbinkimbi ngendlela emangalisayo, futhi ososayensi basaqala ukuhlola ukuthi ukuvuvukala nokudla kungaxhunyaniswa kanjani.
Kungenzeka ukuthi impilo yonke yokudla kwakho nendlela yokuphila ithinta ingcuphe yakho yokuvuvukala okungapheli kanye nezimo ezihlobene nayo, kunokuba kube imbangela eyodwa yokudla.
Ngakho-ke, ukuze ugcine wena namathumbu akho niphilile, kungcono kakhulu ukugxila endleleni yokuphila enempilo iyonke enokuvivinya umzimba okuningi nokudla okusekelwe ekudleni kwangempela, inqwaba ye-prebiotic fiber, nokudla okuncane okungenamsoco.
