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GLP-1 zvinodhaka seOzempic uye Wegovy

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Chiremba vachitaura nemurwere.

  • Tsvagiridzo nyowani yakapihwa kuAmerican Heart Association Scientific Sessions inoratidza kuti semaglutide, iyo inoshanda muOzempic neWegovy, ine zvakakosha pahutano hwemoyo.
  • Humbowo hwakaratidza kuti varwere vanorapwa neGLP-1 vaive nenjodzi yakadzikira yekurova kwemoyo uye sitiroko.
  • Zviratidzo zvekushaya simba kwemoyo zvakare zvakagadziridzwa panguva yekurapa ne semaglutide.

Semaglutide, mushonga weGLP-1 wakatanga kunyorerwa chirwere cheshuga uyezve kufutisa, unogona kukurumidza kurapa chirwere chemoyo.

Mukupera kwesvondo, kuAmerican Heart Association Scientific Sessions 2023, vatsvakurudzi vakapa humbowo hunogutsa hwekushanda kwe semaglutide (inotengeswa pasi pezita rechiratidzo Wegovy neOzempic) mukudzivirira kurohwa kwemoyo nekurohwa.

Imwe tsvagiridzo yakaratidzawo kuti mushonga uyu unogona kushandiswa kuvandudza zviratidzo kune varwere vane moyo kutadza, kunyanya kutadza kwemoyo neyakachengetwa ejection chikamu (HFpEF).

Zvakatorwa pamwe chete, zvidzidzo zviviri izvi, izvo zvakazobudiswa mumagazini makuru ezvokurapa, zvinoratidza chivimbiso che semaglutide senzira yekurapa kune varwere vari pangozi yezviitiko zvakakomba zvemwoyo uye kukanganisa kwemoyo.

Muzviitiko zvese izvi, tsvagiridzo iyi yakatsigirwa naNovo Nordisk, mugadziri weOzempic uye Wegovy.

Ko semaglutide ine yemoyo inobatsira here?

Ongororo yakapihwa vhiki ino uye yakabudiswa panguva imwe chete muNew England Journal of Medicine yakaongorora mhedzisiro kubva ku SELECT kuedza, multicenter, double-blind, randomized, placebo-controlled controlled trial yakaitwa naNovo Nordisk kuti idzidze migumisiro yemwoyo kune varwere vanobatwa semaglutide. zvinopesana ne placebo.

Tsvagiridzo yakapihwa kupera kwesvondo rino inotarisa huwandu hwevanhu vanofa, kusiri kuuraya kurwisa kwemoyo uye sitiroko isingaurayi muvarwere vasina chirwere cheshuga. Mushonga wacho wakamboratidzwa kuderedza zviitiko izvi kune varwere vane chirwere cheshuga chechipiri.

Kuedzwa uku ndiko kukurusa kwakamboitwa nekambani yeDenmark inogadzira mishonga uye kwakabata vanhu vanopfuura zviuru gumi nezvinomwe munyika makumi mana neimwe.

Chidzidzo ichi chakaitwa pakati paGumiguru 2018 naKurume 2021 uye chakatora makore mashanu, kusanganisira nguva yekutevera murwere.

Munguva yekutongwa, hafu yevatori vechikamu yakagamuchira semaglutide (chiyero che 2,4 mg kamwe pavhiki), asi imwe hafu yakagamuchira placebo. Varwere mukutongwa vakanga vakwegura 45 kana kupfuura, vaiva neBMI ye27 kana kupfuura, uye vaiva nechirwere chemwoyo chisati chavapo. Vaifanira kunge vasina nhoroondo yechirwere cheshuga.

Varwere vakatora semaglutide vaiva nengozi yavo yezvinetso zvakakomba zvemwoyo zvakaderedzwa pasi rose: njodzi yakawanda yechiitiko chemwoyo yakaderera ne20%, njodzi yekurwadziwa kwemoyo ne28%, uye njodzi yekurohwa ne7%.

Paivawo nezvimwe zvinobatsira. Iro semaglutide boka rakarasikirwa ne9,39% yehuremu hwemuviri wavo, zvichienzaniswa nechepasi pe1% yeboka re placebo. Vakaonawo kuvandudzwa muropa ravo, cholesterol mazinga uye HbA1c mazinga.

Novo Nordisk yakamboburitsa dhata rekutanga pane iyo SELECT miedzo yemhedzisiro muna Nyamavhuvhu.

Semaglutide inobatsira here nekushaya moyo?

Tsvagiridzo yakaburitswa munaNovember 12 mukati Circulationthe flagship publication yeAmerican Heart Association, yakadzidza semaglutide kurapwa kuti ivandudze zviratidzo zvekukundikana kwemoyo nekuchengetedzwa kwejection fraction, iyo inowanzozivikanwa yekushaya mwoyo.

Vatsvakurudzi vakatarisa matanho akasiyana-siyana munzvimbo dzakadai sehupenyu hwehupenyu, zvigaro zvemagariro evanhu, uye zvikanganiso zvemuviri vachishandisa Kansas City Cardiomyopathy Questionnaire (KCCQ), iyo inopa mucherechedzo wezviratidzo zvekukundikana kwemoyo zvichibva pane zvakatevedzana zvezvikonzero.

Iyo 52-vhiki, randomized, kaviri-mapofu, placebo-inodzorwa muedzo waisanganisira 529 vatori vechikamu. Hafu yevatori vechikamu yakagamuchira jekiseni yevhiki nevhiki ye2,4 mg ye semaglutide, asi imwe hafu yakagamuchira placebo. Varwere vaifanira kuve nekufutisa pamwe nenhoroondo yakanyorwa yeHFpEF.

Vanhu vanobatwa ne semaglutide vakawana kuvandudzwa kukuru kwezviratidzo zvekukundikana kwemoyo, zvinoratidzirwa nekuvandudzwa kweKCCQ chikamu, kuderera kukuru kwehuremu hwemuviri, uye kuvandudzwa kwekushaya simba uye kurovedza muviri basa.

“Iko zvino tave panhongonya yedata iri iro rinotiratidza kuti kufutisa ndiko kuri kukonzera matambudziko aya. Kuti tibudirire kugadzirisa matambudziko aya, tinofanira kugadzirisa kufutisa, tinoda kunanga kufutisa, "Dr. Mikhail Kosiborod, chiremba wemwoyo, mutevedzeri wemutungamiri wekutsvakurudza paSaint Luke's Health System uye munyori mukuru wekudzidza. kudzidza, akaudza Healthline.

Mhedzisiro yacho inovaka pane zvakambowanikwa zvakaburitswa kutanga kwegore rino.

HFpEF inoreva zvakasiyana-siyana zvekutadza kwemoyo umo moyo wakaoma zvakanyanya kuti uzadze zvakanaka.

Kunyangwe kutadza kwemoyo uye kufutisa kwakasiyana mamiriro ehutano, anowanzoitika pamwe chete. Wongororo mu JAMA Pakutanga gore rino, zvakaonekwa kuti vanhu vane uremu hwepamusoro kana kuti vakafutisa BMIs vaive nenjodzi yakanyanya yeHFpEF.

Dr. Lynne Warner Stevenson, purofesa wemishonga yemwoyo paVanderbilt uye mutungamiriri wepurogiramu yavo ye cardiomyopathy, uyo akanga asina kubatanidzwa nekutsvakurudza, akaudza Healthline:

“Ndiwo mapeji esaisai aya akasimukira kuedza kutsvaga nzira dzekudzikisa hurwere nerufu rwandinoona seVenn diagram yechirwere chinova kufutisa, chirwere cheshuga nemoyo. kutadza nechikamu chejection chakachengetedzwa.

GLP-1 mishonga inobatsira kurapa chirwere cheshuga, kufutisa uye chirwere chemoyo

"Ini ndinofunga munhu wese ari kufara uye isu tese tanga takamirira, kunyanya kuyedza SELECT, uye ndinofunga inhau dzakanaka," akadaro Dr. Sun Kim, purofesa wezvemishonga mu endocrinology paThe University kubva kuStanford, akaudza Healthline. Haana kutora chikamu mukutsvagisa.

"Endocrinologists vane hukama hwakasiyana hwekirasi iyi yemishonga nekuti yakatanga kubvumidzwa kurapwa kwerudzi rwe2 chirwere cheshuga uye chekutonga shuga muropa, asi vakaratidzwa kuti vane zvimwe zvakawanda zvinobatsira," akadaro.

Vanyori vechikamu chinoperekedza mu NEJM akanyora kuti: “Tava munguva itsva yekurapa kufutisa uye njodzi yeCardiometabolic nekuwedzera kuri kuita sarudzo. Iyo SELECT muyedzo inopa humbowo hwekuvandudzwa kwechirwere chemoyo mhedzisiro neGLP-1 receptor agonist mukushaikwa kwechirwere cheshuga.

Zvisinei, vakacherechedzawo kuti mari uye kuwanikwa kwe semaglutide inoramba iri zvipingamupinyi zvakakosha kuvanhu vakawanda.

Novo Nordisk yakaisa chikumbiro chekuvandudza label yeWegovy kuti ibatanidze chiratidzo chekudzikisa zviitiko zvakakomba zvemoyo. Iyo FDA yakapa iyo yekutanga ongororo yekuwedzera iyi yekuwedzera mushonga mutsva.

Kambani iyi yakapa Healthline chirevo chinotevera kubva kuna Dr. Michelle Skinner, PharmD, cardiorenal therapy area leader, zvekurapa kuNovo Nordisk:

"Mhedzisiro yakakwana yeSARU yakaunzwa kuAHA chiratidzo chekuchinja musainzi yekufutisa. Tinotarisira kushanda nevatongi pamatanho anotevera ekupa iyi sarudzo kune vanhu vane uremu hwepamusoro kana kuti vakafutisa uye vatapi vehutano vanobatana mukutarisira kwavo.

Izvo zvakakosha

Humbowo huri kubuda hunoratidza kuti semaglutide inogona kunge iine mabhenefiti akakosha pahutano hwemoyo uye kutadza kwemoyo.

Zvinoenderana nedata kubva kuNovo Nordisk's SELECT muyedzo, varwere vanobatwa nesemaglutide vaive ne20% yakaderedzwa njodzi yese yezvakakomba zvakashata zvemoyo zviitiko zvichienzaniswa ne placebo.

Muedzo wakasiyana wakaratidzawo kuti mushonga uyu waishanda mukurapa zviratidzo zvekutadza kwemoyo nechikamu chakachengetedzwa chejection.

VERENGA ZVAKAWANDA VERENGA ZVAKAWANDA VERENGA ZVAKAWANDA VERENGA ZVAKAWANDA VERENGA ZVAKAWANDA VERENGA ZVAKAWANDA

Chikafu Chinogona Kuita seMushonga Zvese Zvaunoda Kuziva

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Zvaunosarudza Kudya Zvine Mhedzisiro Yakakura Pahutano Hwako Hwakazara.Research inoratidza kuti madyiro anokonzera zvirwere. Nepo zvimwe zvikafu zvichigona kukonzeresa hutano husingaperi, zvimwe zvinopa hunhu hwakasimba hwekurapa uye hwekudzivirira.

Saka, vanhu vakawanda vanokakavara kuti zvokudya mushonga.

Zvisinei, kudya chete hakugoni uye hakufaniri kutsiva mushonga mumamiriro ose ezvinhu. Kunyange zvazvo zvirwere zvakawanda zvichigona kudzivirirwa, kurapwa, kana kurapika kuburikidza nekuchinja kwekudya nemararamiro, zvimwe zvakawanda hazvigone.

Ichi chinyorwa chinotsanangura mishonga yemishonga yezvokudya, kusanganisira izvo zvekudya zvinofanira uye zvisingafaniri kushandiswa kuporesa.

Zvokudya semushonga

Madyiro Anoita Chikafu uye Anodzivirira Muviri Wako

Mishonga yakawanda iri muchikafu inosimudzira hutano uye inodzivirira muviri wako kubva kuzvirwere.

Kudya zvakakwana, chikafu chinovaka muviri kwakakosha nekuti zvinhu zvavo zvakasarudzika zvinoshanda synergistically kugadzira mhedzisiro isingagone kudzokororwa nekutora chekuwedzera.

Vitamine uye zvicherwa

Kunyange zvazvo muviri wako uchingoda zvishoma zvevhitamini nemaminerari, zvakakosha kuutano hwako.

Nekudaro, kudya kwekuMadokero - kwakakwira muzvikafu zvakagadziridzwa uye kushoma mukudya kwakazara senge zvigadzirwa zvitsva - kazhinji kacho kushomeka kwemavhitamini nemamineral. Izvi zvinogona kuwedzera zvakanyanya njodzi yako yechirwere ().

Semuenzaniso, kudya kwakakwana kwevhitamini D uye folic acid kunogona kukuvadza mwoyo wako, kukonzera kusagadzikana kwekudzivirira muviri, uye kuwedzera njodzi yako yemamwe magomarara, zvichiteerana (, , ).

Beneficial plant compounds

Zvokudya zvinovaka muviri, zvinosanganisira miriwo, michero, bhinzi uye zviyo, zvine zvakawanda zvinobatsira, senge antioxidants.

chengetedza maseru kubva mukukuvadzwa kungangotungamira kuchirwere ().

Muchokwadi, zvidzidzo zvinoratidza kuti vanhu vane kudya kwakapfuma mu polyphenol antioxidants vane mwero wakaderera wekuora mwoyo, dementia, uye chirwere chemoyo (,,,,).

Fibre

Fiber chikamu chakakosha chekudya kune hutano. Haisi kungokurudzira kugayiwa kwakanaka uye kubvisa, asiwo inodyisa iyo ().

Saka, semiriwo, bhinzi, zviyo uye michero, zvinodzivirira kubva kuchirwere, kuderedza kuzvimba uye kusimbisa immune system yako ().

Kune rumwe rutivi, kudya kwakaderera-fiber kunobatanidzwa nehuwandu hwehuwandu hwezvirwere, kusanganisira kenza yekoloni uye sitiroko (,,,,).

Mapuroteni uye ane hutano mafuta

Mapuroteni nemafuta kubva kuzere, chikafu chinovaka muviri chinoita mabasa akasiyana akakosha mumuviri wako.

- zvivako zvekuvaka mapuroteni - kukurudzira kushanda kwemuviri, kugadzirwa kwemisumbu, metabolism uye kukura, asi mafuta anopa mafuta uye anobatsira kutora mishonga (,).

, iyo inowanikwa muzvikafu zvakaita sehove dzine mafuta, inobatsira kudzora kuzvimba uye yakabatana nemoyo uri nani uye hutano hwekudzivirira zvirwere ().

Summary Zvokudya zvose, zvinovaka muviri zvine mavhitamini, zvicherwa, antioxidants, fiber, mapuroteni nemafuta, izvo zvose zvinokurudzira hutano uye zvakakosha pakushanda kwakakwana kwemuviri.

Kudya kunovaka muviri kunogona kuderedza njodzi yechirwere

Sezvineiwo, kudya kunovaka muviri kunogona kuderedza njodzi yako yehosha, nepo zvakapesana zviri zvechokwadi kune zvakabikwa zvakanyanya.

Kusarudzwa kwezvokudya zvisina kunaka kunogona kuwedzera njodzi yechirwere

Zvokudya zvisina hutano zvakakwirira muzvinwiwa zvine shuga, chikafu chekukurumidza uye zviyo zvakanatswa zvinonyanya kubatsira kuzvirwere zvakaita sehosha yemoyo, chirwere cheshuga uye kufutisa.

Izvi zvikafu zvakagadziriswa zvinokuvadza mabhakitiriya ako emudumbu uye zvinosimudzira insulin kuramba uye njodzi yechirwere chese ().

Ongororo yevanopfuura zviuru zana vanhu yakawana kuti yega yega yegumi muzana yekuwedzera mukushandiswa kwechikafu kwekupedzisira kwakakonzera kuwedzera kwe100% munjodzi yegomarara ().

Pamusoro pezvo, chidzidzo cheNyika neChirwere chakaratidza kuti muna 2017, kufa kwemamiriyoni gumi nerimwe uye 11 miriyoni yakagadziriswa makore ehupenyu (DALYs) ingangove yakakonzerwa nekudya kwakashata ().

DALYs inoyera mutoro wechirwere, chikwata chinomiririra kurasikirwa kwegore rimwe rehutano hwakakwana ().

Zvokudya zvinovaka muviri zvinodzivirira zvirwere

Nekune rimwe divi, tsvakiridzo inoratidza kuti kudya kwakakwira mukudya kwezvirimwa uye kushomeka kwechikafu chakagadzirwa kunowedzera hutano hwako.

Semuenzaniso, chikafu cheMediterranean, chakapfuma mumafuta ane hutano, zviyo nemiriwo, zvinosanganiswa nekuderedzwa kwechirwere chemoyo, neurodegenerative zvirwere, chirwere cheshuga, mamwe kenza uye kufutisa (, , ).

Mimwe miitiro yekudya iyo yakaratidzwa kudzivirira kubva kuhosha inosanganisira zvirimwa, chikafu chose, uye (,) chikafu.

Muchokwadi, kumwe kudya kunogona kushandura mamwe mamiriro.

Semuenzaniso, kudya kwezvirimwa zvakawanikwa kuti zvigadzirise chirwere chemwoyo, nepo mararamiro akaderera-carb anogona kubatsira kubvisa rudzi rwechirwere cheshuga mune vamwe vanhu (,).

Uyezve, kudya kunovaka muviri senge kwakabatana nehupenyu huri nani hwekuzvizivisa uye mwero wakaderera wekuora mwoyo pane zvakajairwa zvekuMadokero - uye zvinogona kutowedzera hupenyu hwako (, , ).

Mhedzisiro iyi inoratidza kuti kudya kwakasimba kunoshanda zvechokwadi semishonga yekudzivirira.

Summary Kutevera kudya kunovaka muviri kunogona kuwedzera hupenyu hurefu, kudzivirira kubva kuzvirwere, nekuvandudza hupenyu hwako hwese.

Zvokudya zvinogona kurapa zvirwere here?

Kunyange zvazvo dzimwe sarudzo dzechikafu dzichigona kudzivirira kana kuwedzera njodzi yako yehosha, hazvisi zvirwere zvese zvinogona kudzivirirwa kana kurapwa kuburikidza nekudya chete.

Zvimwe zvinhu zvakawanda zvinokanganisa hutano hwako uye njodzi yechirwere

Ngozi yechirwere yakaoma kunzwisisa. Kunyange zvazvo kudya kwakashata kuchigona kukonzera kana kuparira hosha, pane zvimwe zvinhu zvakawanda zvokufunga nezvazvo.

Genetics, kusvibiswa, zera, hutachiona, njodzi dzebasa uye sarudzo dzemararamiro - sekushaikwa kwekurovedza muviri, kuputa uye - zvakare zvine chekuita (, , , ).

Chikafu hachikwanisi kubhadhara mararamiro asina kunaka, maitiro ekuberekwa, kana zvimwe zvinhu zvine chokuita nekukura kwechirwere.

Chikafu hachifanirwe kushandiswa sechinotsiva mushonga

Kunyangwe kuchinjira kukudya kunovaka muviri kuchigona kudzivirira chirwere, zvakakosha kuti unzwisise kuti chikafu hachigone uye hachifanire kutsiva mushonga.

Mushonga wakagadzirwa kuponesa hupenyu nekurapa zvirwere. Kunyangwe ichigona kunyorerwa kana kushandiswa sechigadziriso chiri nyore, inowanzokosha.

Nekuti kuporeswa hakubvi pakudya chete kana mararamiro, kusarudza kurega kurapwa kunoponesa hupenyu kuti ungotarisa nezvekudya kunogona kuve nengozi uye kutouraya.

Ngwarira zviziviso zvenhema

Nepo humbowo hwesainzi hunoratidza kuti chikafu chinogona kubatsira neakasiyana ehutano mamiriro, anecdotal zvirevo zvekuporesa kana kurapa zvirwere kuburikidza nekudya zvakanyanya kana dzimwe nzira dzinowanzo nhema.

Semuenzaniso, kudya kwakashambadzirwa kana mamwe mamiriro akakomba kazhinji haatsigirwe netsvagiridzo uye anowanzo kudhura zvakanyanya.

Kudzivisa marapirwo akajairika senge chemotherapy kune mamwe maitiro asina kuratidzwa anogona kuwedzera zvirwere kana kutungamirira kurufu (,,).

Summary Kunyange zvazvo zvokudya zvakawanda zvine betsero dzakasimba mukurwisana nehosha, kudya hakufaniri kurangarirwa sechinotsiva mushonga wenguva dzose.

Zvokudya zvine simba remishonga


Kushandura kune chikafu chekudya chakazara chinogona kuvandudza hutano hwako nenzira dzisingaverengeki. Zvokudya zvinopa mabhenefiti ane simba zvakanyanya zvinosanganisira:

  • Berries. Zvidzidzo zvakawanda zvakaratidza kuti zvinovaka muviri uye zvinomera zvinomera mumabriji zvinorwisa zvirwere. Muchokwadi, chikafu chakapfuma mairi chinogona kudzivirira kubva kuzvirwere zvisingaperi, kusanganisira mamwe kenza ().
  • Cruciferous muriwo. Cruciferous miriwo senge broccoli nekare ine huwandu hwakawanda hwe antioxidants. Kunyanya kushandiswa kwemiriwo iyi kunogona kuderedza njodzi yako yechirwere chemoyo uye kukurudzira hupenyu hurefu ().
  • Hove dzine mafuta. Salmon, sardines, uye dzimwe hove dzine mafuta dzinorwisa kuzvimba nekuda kwehuwandu hwadzo hweomega-3 fatty acids, iyo inodzivirirawo kubva kuchirwere chemoyo ().
  • Howa. Mishonga muhowa, kusanganisira maitake uye reishi, zvakaratidzwa kusimbisa immune system yako, moyo, uye uropi ().
  • Zvinonhuwira. Turmeric, ginger, sinamoni uye zvimwe zvinonhuwira zvakazara nemishonga inobatsira yemiti. Semuenzaniso, zvidzidzo zvinoti zvinobatsira kurapa arthritis uye metabolic syndrome (,).
  • Herbs. Mishonga yakaita separsley, oregano, rosemary, uye sage haingowedzeri kunhuhwirira kwechisikigo mundiro, asiwo ine zvakawanda zvinokurudzira hutano ().
  • Green tea. Green tii yakatsvagirwa zvakanyanya kune yayo inoshamisa mabhenefiti, ayo anogona kusanganisira kudzikiswa kuzvimba uye njodzi yakaderera yechirwere ().

Nzungu, mhodzi, maavocado, mafuta emuorivhi, uchi, masowe egungwa, uye zvikafu zvakaviriswa zvinongova zvishoma zvezvimwe zvakawanda zvekudya zvakadzidzwa nezvemishonga yavo (,,,,,,,).

Kungochinjira kune chikafu chakapfuma mune yakazara chikafu semichero nemiriwo ndiyo nzira iri nyore yekohwa mushonga wekudya.

Summary Maberry, cruciferous miriwo, hove dzine mafuta, uye howa ingori sarudzo yezvikafu zvinopa mishonga ine simba.

Izvo zvakakosha

Zvokudya zvinoita zvinopfuura kungokupa mafuta. Izvi zvinogona kukurudzira kana kuwedzera hutano, zvichienderana nezvaunodya.

Kudya kwakapfuma kwemuviri kwakaratidzwa kudzivirira zvirwere zvakawanda zvisingaperi uye kunogona kubatsira kubata mamwe mamiriro, akadai serudzi rwechipiri chirwere cheshuga.

Kunyange zvazvo zviri pachena kuti kutevera chimwe chezvinhu zvakakosha pakurarama hupenyu hurefu uye hune hutano, ramba uchifunga kuti haufaniri kuvimba nechikafu kuti utsive mishonga yakajairika.

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