GLP-1 kwayoyi kamar Ozempic da Wegovy

Janairu 15 2024

Likita yana magana da mara lafiya.

Sabon binciken da aka gabatar a Cibiyar Nazarin Kimiyya ta Ƙungiyar Zuciya ta Amirka ya nuna cewa semaglutide, mai aiki a cikin Ozempic da Wegovy, yana da tasiri mai mahimmanci akan lafiyar zuciya.
Shaidu sun nuna cewa marasa lafiya da aka yi wa maganin GLP-1 sun rage haɗarin bugun zuciya da bugun jini.
Alamun gazawar zuciya kuma sun inganta yayin jiyya tare da semaglutide.

Semaglutide, maganin GLP-1 da aka fara wajabta don ciwon sukari sannan kuma kiba, zai iya magance cututtukan zuciya da jijiyoyin jini.

A karshen mako, a Cibiyar Nazarin Kimiyyar Zuciya ta Amurka 2023, masu bincike sun gabatar da kwararan hujjoji na tasirin semaglutide (wanda aka sayar a ƙarƙashin alamun Wegovy da Ozempic) don hana bugun zuciya da bugun jini.

Wani bincike kuma ya nuna cewa za a iya amfani da miyagun ƙwayoyi don inganta bayyanar cututtuka a cikin marasa lafiya da ciwon zuciya, musamman rashin ciwon zuciya tare da ɓangarorin cirewa (HFpEF).

A hade, binciken biyu, wanda aka buga daga baya a cikin manyan mujallu na likita, sun nuna alƙawarin don semaglutide a matsayin zaɓi na magani ga marasa lafiya da ke cikin haɗarin manyan cututtukan zuciya da cututtukan zuciya.

A cikin duka biyun, Novo Nordisk, wanda ya yi Ozempic da Wegovy ne ya dauki nauyin binciken.

Shin semaglutide yana da fa'idar bugun jini?

Wani binciken da aka gabatar a wannan karshen mako kuma an buga shi lokaci guda a cikin New England Journal of Medicine yayi nazarin sakamakon daga gwajin SELECT, mai yawa, makafi biyu, bazuwar, gwajin gwajin wuribo wanda Novo Nordisk ya gudanar don nazarin sakamakon cututtukan zuciya a cikin marasa lafiya da aka bi da su tare da semaglutide. da placebo.

Binciken da aka gabatar a karshen mako ya yi nazari kan adadin mace-macen da ake samu, da ciwon zuciya da ba sa mutuwa, da kuma bugun jini a cikin marasa lafiya da ba su da ciwon sukari. An nuna magungunan a baya don rage waɗannan abubuwan da ke faruwa a cikin marasa lafiya da nau'in ciwon sukari na 2.

Gwajin dai ita ce mafi girma da kamfanin harhada magunguna na kasar Denmark ya taba gudanarwa kuma ya hada da mahalarta sama da 17 a kasashe 000.

An gudanar da binciken tsakanin Oktoba 2018 da Maris 2021 kuma ya dade shekaru biyar, ciki har da lokacin bin haƙuri.

A lokacin gwajin, rabin mahalarta sun sami semaglutide (kashi na 2,4 MG sau ɗaya a mako), yayin da sauran rabin sun sami placebo. Marasa lafiya a cikin gwajin sun kasance shekaru 45 ko tsufa, suna da BMI na 27 ko mafi girma, kuma suna da cututtukan zuciya da suka rigaya. Dole ne ba su da tarihin ciwon sukari.

Marasa lafiya waɗanda suka ɗauki semaglutide sun sami raguwar haɗarin matsalolin cututtukan zuciya da yawa a cikin jirgi: haɗarin haɗarin cututtukan zuciya ya ragu da 20%, haɗarin bugun zuciya da 28%, da haɗarin bugun jini ta 7%.

Akwai ƙarin fa'idodi kuma. Ƙungiyar semaglutide ta rasa 9,39% na nauyin jikinsu, idan aka kwatanta da kasa da 1% na rukunin placebo. Sun kuma ga inganta hawan jini, matakan cholesterol da matakan HbA1c.

Novo Nordisk a baya ya fitar da bayanan asali akan sakamakon gwaji na SELECT a watan Agusta.

Shin semaglutide yana taimakawa tare da gazawar zuciya?

Binciken da aka buga a ranar Nuwamba 12 a CirculationBuga flagship na Ƙungiyar Zuciya ta Amurka, ta yi nazarin maganin semaglutide don inganta alamun gazawar zuciya tare da ɓangarorin da aka adana, mafi yawan nau'in ciwon zuciya.

Masu bincike sun kalli matakan daban-daban a wurare kamar ingancin rayuwa, ƙayyadaddun zamantakewa, da ƙayyadaddun jiki ta amfani da Kansas City Cardiomyopathy Questionnaire (KCCQ), wanda ke ba da maki ga alamun rashin ciwon zuciya bisa jerin dalilai.

Makonni 52, bazuwar, makafi biyu, gwajin sarrafa wuribo ya haɗa da mahalarta 529. Rabin mahalarta sun sami allurar mako-mako na 2,4 MG na semaglutide, yayin da sauran rabin sun sami placebo. Dole ne marasa lafiya su sami kiba da kuma tarihin da aka rubuta na HFpEF.

Mutanen da aka bi da su tare da semaglutide sun sami ci gaba mai mahimmanci a cikin alamun gazawar zuciya, wanda aka nuna ta hanyar haɓakawa a cikin ƙimar KCCQ, raguwa mafi girma a cikin nauyin jiki, da haɓakawa a cikin iyakokin jiki da aikin motsa jiki.

"Yanzu muna kan wannan bala'in bayanan da ke nuna mana da gaske kan cewa kiba ce ke haifar da wadannan rikice-rikice. Domin gudanar da waɗannan matsalolin yadda ya kamata, muna buƙatar magance kiba, muna buƙatar ƙaddamar da kiba, "Dokta Mikhail Kosiborod, likitan zuciya, mataimakin shugaban bincike a Tsarin Kiwon Lafiya na Saint Luke da jagoran marubucin binciken. binciken, in ji Healthline.

Sakamakon ya dogara ne akan binciken da aka buga a baya a farkon wannan shekara.

HFpEF yana nufin nau'in raunin zuciya iri-iri wanda zuciyar ta yi taurin kai don cikawa da kyau.

Kodayake gazawar zuciya da kiba yanayi ne na kiwon lafiya daban, galibi suna faruwa tare. A review in Jama A farkon wannan shekarar, an gano cewa mutanen da ke da kiba ko kiba BMI suna da haɗarin HFpEF da yawa.

Dokta Lynne Warner Stevenson, farfesa na likitancin zuciya a Vanderbilt da kuma darektan shirin su na cardiomyopathy, wanda ba shi da alaƙa da binciken, ya gaya wa Healthline:

“Karshen wannan guguwar ce ta bullo da ita don neman hanyar da za a bi don rage cututtuka da mace-macen abin da na dauka a matsayin hoton Venn na cututtuka, wato kiba da ciwon suga da cututtukan zuciya. gazawar da aka adana juzu'in fitarwa.

Magungunan GLP-1 suna taimakawa wajen magance ciwon sukari, kiba da cututtukan zuciya

"Ina tsammanin kowa yana jin dadi kuma duk mun jira, musamman gwajin SELECT, kuma ina ganin labari ne mai kyau," in ji Dokta Sun Kim, mataimakin farfesa a fannin likitanci a cikin ilimin endocrinology a Jami'ar Stanford, ya shaida wa Healthline. Ba ta shiga cikin binciken ba.

"Masu ilimin endocrinologists suna da alaƙa ta musamman ga wannan rukunin magungunan saboda an fara yarda da su don maganin ciwon sukari na 2 da kuma kula da sukarin jini, amma an nuna cewa suna da ƙarin fa'idodi da yawa," in ji ta.

Marubutan edita mai rakiya a cikin NEJM ya rubuta: "Muna cikin sabon zamani na magance kiba da haɗarin cardiometabolic tare da haɓakar arsenal na zaɓuɓɓuka. Gwajin SELECT yana ba da shaida na ingantattun sakamakon cututtukan zuciya tare da GLP-1 agonists masu karɓa a cikin rashin ciwon sukari.

Koyaya, sun kuma lura cewa farashi da samun damar yin amfani da semaglutide ya kasance babban cikas ga mutane da yawa.

Novo Nordisk ya shigar da aikace-aikace don sabunta alamar Wegovy don haɗawa da nuni don rage manyan abubuwan da suka faru na zuciya da jijiyoyin jini. FDA ta ba da fifikon sabuntawa don wannan ƙarin sabon aikace-aikacen magani.

Kamfanin ya ba da Healthline tare da bayanin mai zuwa daga Dr. Michelle Skinner, PharmD, jagoran yanki na likitancin zuciya, al'amuran kiwon lafiya a Novo Nordisk:

“Cikakken sakamakon SELECT da aka gabatar a AHA alama ce ta juyi a kimiyyar kiba. Muna sa ran yin aiki tare da masu gudanarwa kan matakai na gaba don samar da wannan zaɓi ga mutanen da ke da kiba ko kiba da kuma ma'aikatan kiwon lafiya waɗanda ke haɗin gwiwa a cikin kulawarsu.

Mai

Shaidu masu tasowa sun nuna cewa semaglutide na iya samun fa'idodi masu mahimmanci akan lafiyar zuciya da gazawar zuciya.

Dangane da bayanai daga gwaji na Novo Nordisk's SELECT, marasa lafiya da aka yi musu magani tare da semaglutide sun rage kashi 20% gabaɗayan haɗarin mummunan cututtukan zuciya da jijiyoyin jini idan aka kwatanta da placebo.

Wani gwaji na daban kuma ya nuna maganin yana da tasiri wajen magance alamun gazawar zuciya tare da tsayayyen juzu'in fitarwa.

KARA KARANTAWA KA KARA KARANTAWA KA ARA KARA KARANTAWA KA ARA KARA KARANTAWA

Za a iya yin aiki da Abinci azaman magani Duk abin da kuke buƙatar sani

admin

Yuli 19 2020

Abin da kuka zaɓa don ci yana da tasirin gaske akan lafiyar ku gabaɗaya.Bincike ya nuna cewa halaye na abinci yana tasiri haɗarin cututtuka. Yayin da wasu abinci na iya haifar da yanayin kiwon lafiya na yau da kullun, wasu suna ba da ingantaccen magani da halayen kariya.

Don haka, mutane da yawa suna jayayya cewa abinci magani ne.

Duk da haka, abinci kadai ba zai iya kuma bai kamata ya maye gurbin magani a kowane yanayi ba. Ko da yake ana iya rigakafin cututtuka da yawa, ko ma magani, ko ma warkewa ta hanyar canjin abinci da salon rayuwa, wasu da yawa ba za su iya ba.

Wannan labarin yana bayanin tasirin magani na abinci, gami da abincin da yakamata kuma bai kamata a yi amfani da su ba don warkarwa.

Yadda Abinci ke Cire Jikinku da Kare

Yawancin abubuwan gina jiki a cikin abinci suna inganta lafiya kuma suna kare jikin ku daga cututtuka.

Cin abinci gaba ɗaya, abinci mai gina jiki yana da mahimmanci saboda abubuwansu na musamman suna aiki tare da juna don ƙirƙirar tasirin da ba za a iya maimaita shi ta hanyar shan kari ba.

Vitamins da ma'adanai

Kodayake jikinka yana buƙatar ƙananan adadin bitamin da ma'adanai, suna da mahimmanci ga lafiyar ku.

Duk da haka, abincin yammacin turai - mai girma a cikin abincin da aka sarrafa da ƙananan abinci gaba ɗaya kamar sabbin kayan abinci - gabaɗaya suna da ƙarancin bitamin da ma'adanai. Wannan na iya ƙara haɗarin kamuwa da cuta ().

Misali, rashin isasshen bitamin D da folic acid na iya lalata zuciyarka, haifar da tabarbarewar rigakafi, da kuma kara haɗarin wasu cututtukan daji, bi da bi (, , ).

Amfanin shuka mahadi

Abinci masu gina jiki, gami da kayan lambu, 'ya'yan itatuwa, wake da hatsi, sun ƙunshi mahadi masu amfani da yawa, irin su antioxidants.

kare kwayoyin halitta daga lalacewa wanda zai iya haifar da cuta ().

A gaskiya ma, nazarin ya nuna cewa mutanen da abincin da ke da wadata a cikin polyphenol antioxidants suna da ƙananan ƙwayar cuta, ƙwaƙwalwa, da cututtukan zuciya (, , ,).

Fiber

Fiber wani muhimmin bangare ne na abinci mai kyau. Ba wai kawai yana haɓaka kyakkyawan narkewa da kawarwa ba, har ma yana ciyar da ().

Don haka, kamar kayan lambu, wake, hatsi da 'ya'yan itatuwa, suna kare kariya daga cututtuka, rage kumburi da ƙarfafa tsarin rigakafi ().

A gefe guda, rage cin abinci mai fiber yana da alaƙa da haɓakar haɗarin cututtuka, gami da ciwon daji na hanji da bugun jini (, , , ).

Protein da lafiyayyen kitse

Sunadaran da mai daga duka, abinci mai gina jiki suna taka muhimmiyar rawa iri-iri a cikin jikin ku.

- tubalan gina jiki na gina jiki - inganta aikin rigakafi, ƙwayar tsoka, haɓakawa da haɓaka, yayin da mai ke ba da man fetur kuma yana taimakawa wajen shayar da abinci mai gina jiki (,).

, wanda aka samo a cikin abinci kamar kifin mai mai, yana taimakawa wajen daidaita kumburi kuma yana da alaƙa da mafi kyawun zuciya da lafiyar jiki ().

Abinda ke ciki Gabaɗaya, abinci mai gina jiki yana ɗauke da bitamin, ma'adanai, antioxidants, fiber, proteins da fats, waɗanda duk suna haɓaka lafiya kuma suna da mahimmanci don ingantaccen aikin jiki.

Abinci mai kyau zai iya rage haɗarin cututtuka

Musamman ma, abinci mai gina jiki na iya rage haɗarin kamuwa da cuta, yayin da akasin haka yake ga abincin da aka sarrafa sosai.

Zaɓin abinci mara kyau na iya ƙara haɗarin cuta

Rashin abinci mai gina jiki mai yawan abin sha, abinci mai sauri da kuma tsaftataccen hatsi da farko suna taimakawa ga cututtuka irin su cututtukan zuciya, ciwon sukari da kiba.

Waɗannan abincin da aka sarrafa suna cutar da ƙwayoyin cuta na hanji kuma suna haɓaka juriya na insulin da haɗarin cutar gaba ɗaya ().

Wani bincike na mutane sama da 100 ya gano cewa duk karuwar kashi 000 cikin 10 na cin abinci da aka sarrafa sosai ya haifar da karuwar 12% na haɗarin cutar kansa ().

Bugu da ƙari, nazarin Duniya da Cututtuka ya nuna cewa a cikin 2017, mutuwar mutane miliyan 11 da shekaru miliyan 255 na nakasassu (DALYs) na iya faruwa saboda rashin abinci mara kyau ().

DALYs suna auna nauyin cuta, sashin da ke wakiltar asarar shekara guda na cikakkiyar lafiya ().

Abincin abinci mai gina jiki yana kare kariya daga cututtuka

A gefe guda kuma, bincike ya nuna cewa cin abinci mai yawa na kayan lambu da ƙarancin abincin da aka sarrafa yana ƙarfafa lafiyar ku.

Alal misali, abincin da ke cikin Rum, mai arziki a cikin kitsen lafiya, dukan hatsi da kayan lambu, yana da alaƙa da rage haɗarin cututtukan zuciya, cututtukan neurodegenerative, ciwon sukari, wasu cututtuka da kiba (, ,).

Sauran tsarin cin abinci da aka nuna don karewa daga cututtuka sun haɗa da tushen shuka, abinci mai gina jiki, da (,) abinci.

A gaskiya ma, wasu abinci na iya juya wasu yanayi.

Misali, an gano nau'in abinci mai gina jiki don juyar da cututtukan zuciya na zuciya, yayin da ƙananan salon rayuwa na iya taimakawa wajen kawar da nau'in ciwon sukari na 2 a wasu mutane (, ).

Bugu da ƙari, halayen cin abinci mai gina jiki kamar suna da alaƙa da ingantaccen rahoton kai da ingancin rayuwa da ƙarancin ɓacin rai fiye da abincin yamma na yau da kullun - kuma yana iya ƙara tsawon rayuwar ku (, , ).

Waɗannan sakamakon sun tabbatar da cewa ingantaccen abinci yana aiki da gaske azaman magungunan rigakafi.

Abinda ke ciki Bin abinci mai kyau zai iya ƙara tsawon rai, kariya daga cututtuka, da inganta rayuwar ku gaba ɗaya.

Shin abinci zai iya magance cututtuka?

Ko da yake wasu zaɓin abinci na iya hanawa ko ƙara haɗarin kamuwa da cuta, ba duk cututtuka ba ne za a iya hana su ko a bi da su ta hanyar abinci kaɗai.

Wasu dalilai da yawa suna shafar lafiyar ku da haɗarin cuta

Hadarin cuta yana da wahala sosai. Ko da yake rashin cin abinci mara kyau na iya haifar ko taimakawa ga cututtuka, akwai wasu abubuwa da yawa da za a yi la'akari da su.

Genetics, gurɓataccen yanayi, shekaru, cututtuka, haɗarin sana'a da zaɓin salon rayuwa - irin su rashin motsa jiki, shan taba da - kuma suna da tasiri (, , , ).

Abinci ba zai iya ramawa ga rashin zaɓin salon rayuwa ba, yanayin halitta, ko wasu abubuwan da suka shafi ci gaban cutar.

Kada a yi amfani da abinci a madadin magani

Ko da yake canzawa zuwa abinci mafi koshin lafiya na iya hana kamuwa da cuta, yana da mahimmanci a fahimci cewa abinci ba zai iya maye gurbin magani ba.

An samar da magani don ceton rayuka da kuma magance cututtuka. Ko da yake ana iya wuce kima ko amfani da shi azaman gyara mai sauƙi, sau da yawa yana da kima.

Domin warkarwa ba ta dogara ga abinci ko salon rayuwa kaɗai ba, zabar barin yuwuwar magani na ceton rai don mai da hankali kan abinci kawai na iya zama haɗari har ma da kisa.

Hattara da tallan karya

Yayin da shaidar kimiyya ta nuna cewa abinci na iya taimakawa tare da yanayin kiwon lafiya iri-iri, da'awar waraka ko magance cututtuka ta hanyar cin abinci mai tsanani ko wasu hanyoyin yawanci ƙarya ne.

Misali, abincin da aka yi talla ko wasu munanan yanayi gabaɗaya bincike baya samun tallafi kuma galibi suna da tsada.

Gujewa jiyya na al'ada kamar chemotherapy don wasu hanyoyin da ba a tabbatar da su ba na iya cutar da cututtuka ko haifar da mutuwa (,,).

Abinda ke ciki Ko da yake yawancin abinci suna da fa'ida mai ƙarfi akan cututtuka, bai kamata a ɗauki abinci a matsayin madadin magani na al'ada ba.

Abincin da ke da kaddarorin magani masu ƙarfi

Canja wurin cin abinci gaba ɗaya na iya inganta lafiyar ku ta hanyoyi marasa adadi. Abincin da ke ba da fa'idodi na musamman sun haɗa da:

Berries. Yawancin bincike sun nuna cewa abubuwan gina jiki da magungunan shuka a cikin berries suna yaki da cututtuka. A gaskiya ma, cin abinci mai arziki a cikinsa na iya kare kariya daga cututtuka masu tsanani, ciki har da wasu cututtuka ().
Cruciferous kayan lambu. Kayan lambu na cruciferous kamar broccoli da Kale sun ƙunshi nau'ikan antioxidants masu yawa. Yawan amfani da waɗannan kayan lambu na iya rage haɗarin cututtukan zuciya da haɓaka tsawon rai ().
Kifi mai mai. Salmon, sardines, da sauran kifaye masu kitse suna yaƙi da kumburi saboda yawan sinadarin omega-3 fatty acids, wanda kuma ke ba da kariya ga cututtukan zuciya ().
Namomin kaza. Abubuwan da ke cikin namomin kaza, gami da maitake da reishi, an nuna su don ƙarfafa tsarin rigakafi, zuciya, da kwakwalwa ().
Kayan yaji. Turmeric, ginger, kirfa da sauran kayan yaji suna cike da mahadi na shuka masu amfani. Alal misali, nazarin ya lura cewa yana taimakawa wajen magance cututtuka na arthritis da kuma ciwo na rayuwa (, ).
Ganye. Ganye kamar faski, oregano, Rosemary, da Sage ba kawai suna ƙara ɗanɗano na halitta ba a cikin jita-jita, har ma sun ƙunshi mahaɗan da ke haɓaka lafiya da yawa ().
Koren shayi. Green shayi an yi bincike sosai don fa'idodinsa masu ban sha'awa, wanda zai iya haɗawa da rage kumburi da ƙananan haɗarin cuta ().

Kwayoyi, iri, avocado, man zaitun, zuma, ciwan ruwa, da abinci masu haifuwa kaɗan ne daga cikin yawancin abincin da aka yi nazari don maganinsu (, , , , , ).

Kawai canzawa zuwa abinci mai wadatar abinci gaba ɗaya kamar 'ya'yan itatuwa da kayan marmari shine hanya mafi sauƙi don samun fa'idodin magani na abinci.

Abinda ke ciki Berries, kayan lambu na cruciferous, kifi mai kitse, da namomin kaza zaɓi ne na abinci waɗanda ke ba da kaddarorin magani masu ƙarfi.

Mai

Abinci yana yin fiye da samar muku da mai. Wannan na iya inganta ko kuma tabarbare lafiya, ya danganta da abin da kuke ci.

An nuna abinci mai gina jiki mai gina jiki don hana yawancin cututtuka masu tsanani kuma yana iya taimakawa wajen magance wasu yanayi, kamar nau'in ciwon sukari na 2.

Duk da yake a bayyane yake cewa bin ɗaya yana ɗaya daga cikin mahimman abubuwan da ke haifar da rayuwa mai tsawo da lafiya, ku tuna cewa bai kamata ku dogara ga abinci don maye gurbin magungunan gargajiya ba.

Tag: médicaments